FTO gene variants are strongly associated with type 2 diabetes in South Asian Indians.

ABSTRACT:

Aims and hypothesis

Variants of the FTO (fat mass and obesity associated) gene are associated with obesity and type 2 diabetes in white Europeans, but these associations are not consistent in Asians. A recent study in Asian Indian Sikhs showed an association with type 2 diabetes that did not seem to be mediated through BMI. We studied the association of FTO variants with type 2 diabetes and measures of obesity in South Asian Indians in Pune.

Methods

We genotyped, by sequencing, two single nucleotide polymorphisms, rs9939609 and rs7191344, in the FTO gene in 1,453 type 2 diabetes patients and 1,361 controls from Pune, Western India and a further 961 population-based individuals from Mysore, South India.

Results

We observed a strong association of the minor allele A at

SUBMITTER: Yajnik CS 

PROVIDER: S-EPMC2658005 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature