Gene expression profiling as a window into idiopathic pulmonary fibrosis pathogenesis: can we identify the right target genes?

ABSTRACT: Expression microarrays that provide genome-level, transcriptional, high-resolution profiles have been applied successfully to multiple diseases. Although microarrays provide information regarding thousands of genes, many investigators prefer to focus on a single gene and validate its role, an approach often supported by grant and journal reviewers. Only a minority of investigators focus on global changes in gene expression. Here, we describe and contrast two general approaches to the use of microarray data: the reductionist "cherry picking" approach and the more global, quantitative "systems" approach. We describe microarray analysis experiments relevant to idiopathic pulmonary fibrosis (IPF) in the context of these two approaches. Although it seems that the cherry-picking approaches have

SUBMITTER: Kaminski N 

PROVIDER: S-EPMC2658685 | biostudies-literature | 2006 Jun

REPOSITORIES: biostudies-literature