Biomechanical Regulation of Endothelium-dependent Events Critical for Adaptive Remodeling.

ABSTRACT: Alterations in hemodynamic shear stress acting on the vascular endothelium are critical for adaptive arterial remodeling. The molecular mechanisms regulating this process, however, remain largely uncharacterized. Here, we sought to define the responses evoked in endothelial cells exposed to shear stress waveforms characteristic of coronary collateral vessels and the subsequent paracrine effects on smooth muscle cells. A lumped parameter model of the human coronary collateral circulation was used to simulate normal and adaptive remodeling coronary collateral shear stress waveforms. These waveforms were then applied to cultured human endothelial cells (EC), and the resulting differences in EC gene expression were assessed by genome-wide transcriptional profiling to identify genes distinctly

SUBMITTER: Mack PJ 

PROVIDER: S-EPMC2659199 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature