Characterisation of the fibroblast growth factor dependent transcriptome in early development.

ABSTRACT:

Background

FGF signaling has multiple roles in regulating processes in animal development, including the specification and patterning of the mesoderm. In addition, FGF signaling supports self renewal of human embryonic stem cells and is required for differentiation of murine embryonic stem cells into a number of lineages.

Methodology/principal findings

Given the importance of FGF signaling in regulating development and stem cell behaviour, we aimed to identify the transcriptional targets of FGF signalling during early development in the vertebrate model Xenopus laevis. We analysed the effects on gene expression in embryos in which FGF signaling was inhibited by dominant negative FGF receptors. 67 genes positively regulated by FGF signaling and 16 genes negatively regulated b

SUBMITTER: Branney PA 

PROVIDER: S-EPMC2659300 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature