Syntheses and biological evaluation of B-ring-modified analogues of dafachronic acid A.

ABSTRACT: Synthesis and testing of dafachronic acid A ( 1) and its derivatives 2 and 3 have revealed that 1, and not a further oxidation product, is the natural ligand for the DAF-12 receptor of Caenorhabditis elegans.

SUBMITTER: Giroux S 

PROVIDER: S-EPMC2659505 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature