Humoral immune responses of dengue fever patients using epitope-specific serotype-2 virus-like particle antigens.

ABSTRACT: Dengue virus (DENV) is a serious mosquito-borne pathogen causing significant global disease burden, either as classic dengue fever (DF) or in its most severe manifestation dengue hemorrhagic fever (DHF). Nearly half of the world's population is at risk of dengue disease and there are estimated to be millions of infections annually; a situation which will continue to worsen with increasing expansion of the mosquito vectors and epidemic DF/DHF. Currently there are no available licensed vaccines or antivirals for dengue, although significant effort has been directed toward the development of safe and efficacious dengue vaccines for over 30 years. Promising vaccine candidates are in development and testing phases, but a better understanding of immune responses to DENV infection and vaccination

SUBMITTER: Crill WD 

PROVIDER: S-EPMC2659788 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature