Cholesterol reduction and non-illness mortality: meta-analysis of randomised clinical trials.

ABSTRACT:

Objective

To investigate the association between cholesterol lowering interventions and risk of death from suicide, accident, or trauma (non-illness mortality).

Design

Meta-analysis of the non-illness mortality outcomes of large, randomised clinical trials of cholesterol lowering treatments.

Studies reviewed

19 out of 21 eligible trials that had data available on non-illness mortality. INTERVENTIONS REVIEWED: Dietary modification, drug treatment, or partial ileal bypass surgery for 1-10 years.

Main outcome measure

Deaths from suicides, accidents, and violence in treatment groups compared with control groups.

Results

Across all trials, the odds ratio of non-illness mortality in the treated groups, relative to control groups, was 1.18 (95% confidence inter

SUBMITTER: Muldoon MF 

PROVIDER: S-EPMC26598 | biostudies-literature | 2001 Jan

REPOSITORIES: biostudies-literature