VEGFA upregulates FLJ10540 and modulates migration and invasion of lung cancer via PI3K/AKT pathway.

ABSTRACT:

Background

Lung adenocarcinoma is the leading cause of cancer-related deaths among both men and women in the world. Despite recent advances in diagnosis and treatment, the mortality rates with an overall 5-year survival of only 15%. This high mortality is probably attributable to early metastasis. Although several well-known markers correlated with poor/metastasis prognosis in lung adenocarcinoma patients by immunohistochemistry was reported, the molecular mechanisms of lung adenocarcinoma development are still not clear. To explore novel molecular markers and their signaling pathways will be crucial for aiding in treatment of lung adenocarcinoma patients.

Methodology/principal findings

To identify novel lung adenocarcinoma-associated /metastasis genes and to clarify the und

SUBMITTER: Chen CH 

PROVIDER: S-EPMC2659802 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature