IL6 and CRP haplotypes are associated with COPD risk and systemic inflammation: a case-control study.

ABSTRACT:

Background

Elevated circulating levels of C-reactive protein (CRP), interleukin (IL)-6 and fibrinogen (FG) have been repeatedly associated with many adverse outcomes in patients with chronic obstructive pulmonary disease (COPD). To date, it remains unclear whether and to what extent systemic inflammation is primary or secondary in the pathogenesis of COPD. The aim of this study was to examine the association between haplotypes of CRP, IL6 and FGB genes, systemic inflammation, COPD risk and COPD-related phenotypes (respiratory impairment, exercise capacity and body composition).

Methods

Eighteen SNPs in three genes, representing optimal haplotype-tagging sets, were genotyped in 355 COPD patients and 195 healthy smokers. Plasma levels of CRP, IL-6 and FG were measured in the t

SUBMITTER: Yanbaeva DG 

PROVIDER: S-EPMC2660301 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature