Identification of novel DNA repair proteins via primary sequence, secondary structure, and homology.

ABSTRACT:

Background

DNA repair is the general term for the collection of critical mechanisms which repair many forms of DNA damage such as methylation or ionizing radiation. DNA repair has mainly been studied in experimental and clinical situations, and relatively few information-based approaches to new extracting DNA repair knowledge exist. As a first step, automatic detection of DNA repair proteins in genomes via informatics techniques is desirable; however, there are many forms of DNA repair and it is not a straightforward process to identify and classify repair proteins with a single optimal method. We perform a study of the ability of homology and machine learning-based methods to identify and classify DNA repair proteins, as well as scan vertebrate genomes for the presence of novel re

SUBMITTER: Brown JB 

PROVIDER: S-EPMC2660303 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature