Evolution of the multifaceted eukaryotic akirin gene family.

ABSTRACT:

Background

Akirins are nuclear proteins that form part of an innate immune response pathway conserved in Drosophila and mice. This studies aim was to characterise the evolution of akirin gene structure and protein function in the eukaryotes.

Results

akirin genes are present throughout the metazoa and arose before the separation of animal, plant and fungi lineages. Using comprehensive phylogenetic analysis, coupled with comparisons of conserved synteny and genomic organisation, we show that the intron-exon structure of metazoan akirin genes was established prior to the bilateria and that a single proto-orthologue duplicated in the vertebrates, before the gnathostome-agnathan separation, producing akirin1 and akirin2. Phylogenetic analyses of seven vertebrate gene families wit

SUBMITTER: Macqueen DJ 

PROVIDER: S-EPMC2660306 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature