Bioinformatic characterizations and prediction of K+ and Na+ ion channels effector toxins.

ABSTRACT:

Background

K+ and Na+ channel toxins constitute a large set of polypeptides, which interact with their ion channel targets. These polypeptides are classified in two different structural groups. Recently a new structural group called birtoxin-like appeared to contain both types of toxins has been described. We hypothesized that peptides of this group may contain two conserved structural motifs in K+ and/or Na+ channels scorpion toxins, allowing these birtoxin-like peptides to be active on K+ and/or Na+ channels.

Results

Four multilevel motifs, overrepresented and specific to each group of K+ and/or Na+ ion channel toxins have been identified, using GIBBS and MEME and based on a training dataset of 79 sequences judged as representative of K+ and Na+ toxins.Unexpectedly birtoxi

SUBMITTER: Soli R 

PROVIDER: S-EPMC2660317 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature