A family of splice variants of CstF-64 expressed in vertebrate nervous systems.

ABSTRACT:

Background

Alternative splicing and polyadenylation are important mechanisms for creating the proteomic diversity necessary for the nervous system to fulfill its specialized functions. The contribution of alternative splicing to proteomic diversity in the nervous system has been well documented, whereas the role of alternative polyadenylation in this process is less well understood. Since the CstF-64 polyadenylation protein is known to be an important regulator of tissue-specific polyadenylation, we examined its expression in brain and other organs.

Results

We discovered several closely related splice variants of CstF-64 - collectively called betaCstF-64 - that could potentially contribute to proteomic diversity in the nervous system. The betaCstF-64 splice variants are foun

SUBMITTER: Shankarling GS 

PROVIDER: S-EPMC2660332 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature