Voltage-gated sodium channels in taste bud cells.

ABSTRACT:

Background

Taste bud cells transmit information regarding the contents of food from taste receptors embedded in apical microvilli to gustatory nerve fibers innervating basolateral membranes. In particular, taste cells depolarize, activate voltage-gated sodium channels, and fire action potentials in response to tastants. Initial cell depolarization is attributable to sodium influx through TRPM5 in sweet, bitter, and umami cells and an undetermined cation influx through an ion channel in sour cells expressing PKD2L1, a candidate sour taste receptor. The molecular identity of the voltage-gated sodium channels that sense depolarizing signals and subsequently initiate action potentials coding taste information to gustatory nerve fibers is unknown.

Results

We describe the molecula

SUBMITTER: Gao N 

PROVIDER: S-EPMC2660338 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature