Understanding Haemophilus parasuis infection in porcine spleen through a transcriptomics approach.

ABSTRACT:

Background

Haemophilus parasuis (HPS) is an important swine pathogen that causes Glässer's disease, which is characterized by fibrinous polyserositis, meningitis and arthritis. The molecular mechanisms that underlie the pathogenesis of the disease remain poorly understood, particularly the resistance of porcine immune system to HPS invasion. In this study, we investigated the global changes in gene expression in the spleen following HPS infection using the Affymetrix Porcine Genechip.

Results

A total of 931 differentially expressed (DE) transcripts were identified in the porcine spleen 7 days after HPS infection; of these, 92 unique genes showed differential expression patterns based on analysis using BLASTX and Gene Ontology. The DE genes involved in the immune response inc

SUBMITTER: Chen H 

PROVIDER: S-EPMC2660370 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature