Immune response to Mycobacterium tuberculosis and identification of molecular markers of disease.

ABSTRACT: The complex molecular events that occur within the host during the establishment of a Mycobacterium tuberculosis infection are poorly defined, thus preventing identification of predictive markers of disease progression and state. To identify such molecular markers during M. tuberculosis infection, global changes in transcriptional response in the host were assessed using mouse whole genome arrays. Bacterial load in the lungs, the lesions associated with infection, and gene expression profiling was performed by comparing normal lung tissue to lungs from mice collected at 20, 40, and 100 days after aerosol infection with the H37Rv strain of M. tuberculosis. Quantitative, whole lung gene expression identified signature profiles defining different signaling pathways and immunological responses

SUBMITTER: Gonzalez-Juarrero M 

PROVIDER: S-EPMC2660559 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature