Phenotypic and functional characterization of human memory T cell responses to Burkholderia pseudomallei.

ABSTRACT:

Background

Infection with the Gram-negative bacterium Burkholderia pseudomallei is an important cause of community-acquired lethal sepsis in endemic regions in southeast Asia and northern Australia and is increasingly reported in other tropical areas. In animal models, production of interferon-gamma (IFN-gamma) is critical for resistance, but in humans the characteristics of IFN-gamma production and the bacterial antigens that are recognized by the cell-mediated immune response have not been defined.

Methods

Peripheral blood from 133 healthy individuals who lived in the endemic area and had no history of melioidosis, 60 patients who had recovered from melioidosis, and 31 other patient control subjects were stimulated by whole bacteria or purified bacterial proteins in vitro,

SUBMITTER: Tippayawat P 

PROVIDER: S-EPMC2660609 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature