Multiple ERK substrates execute single biological processes in Caenorhabditis elegans germ-line development.

ABSTRACT: RAS-extracellular signal regulated kinase (ERK) signaling governs multiple aspects of cell fate specification, cellular transitions, and growth by regulating downstream substrates through phosphorylation. Understanding how perturbations to the ERK signaling pathway lead to developmental disorders and cancer hinges critically on identification of the substrates. Yet, only a limited number of substrates have been identified that function in vivo to execute ERK-regulated processes. The Caenorhabditis elegans germ line utilizes the well-conserved RAS-ERK signaling pathway in multiple different contexts. Here, we present an integrated functional genomic approach that identified 30 ERK substrates, each of which functions to regulate one or more of seven distinct biological processes during C. el

SUBMITTER: Arur S 

PROVIDER: S-EPMC2660749 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature