QVALITY: non-parametric estimation of q-values and posterior error probabilities.

ABSTRACT:

Unlabelled

Qvality is a C++ program for estimating two types of standard statistical confidence measures: the q-value, which is an analog of the p-value that incorporates multiple testing correction, and the posterior error probability (PEP, also known as the local false discovery rate), which corresponds to the probability that a given observation is drawn from the null distribution. In computing q-values, qvality employs a standard bootstrap procedure to estimate the prior probability of a score being from the null distribution; for PEP estimation, qvality relies upon non-parametric logistic regression. Relative to other tools for estimating statistical confidence measures, qvality is unique in its ability to estimate both types of scores directly from a null distribution, withou

SUBMITTER: Kall L 

PROVIDER: S-EPMC2660870 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature