Towards prediction of metabolic products of polyketide synthases: an in silico analysis.

ABSTRACT: Sequence data arising from an increasing number of partial and complete genome projects is revealing the presence of the polyketide synthase (PKS) family of genes not only in microbes and fungi but also in plants and other eukaryotes. PKSs are huge multifunctional megasynthases that use a variety of biosynthetic paradigms to generate enormously diverse arrays of polyketide products that posses several pharmaceutically important properties. The remarkable conservation of these gene clusters across organisms offers abundant scope for obtaining novel insights into PKS biosynthetic code by computational analysis. We have carried out a comprehensive in silico analysis of modular and iterative gene clusters to test whether chemical structures of the secondary metabolites can be predicted from PK

SUBMITTER: Yadav G 

PROVIDER: S-EPMC2661021 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature