Activation of mRNA translation by phage protein and low temperature: the case of Lactococcus lactis abortive infection system AbiD1.

ABSTRACT:

Background

Abortive infection (Abi) mechanisms comprise numerous strategies developed by bacteria to avoid being killed by bacteriophage (phage). Escherichia coli Abis are considered as mediators of programmed cell death, which is induced by infecting phage. Abis were also proposed to be stress response elements, but no environmental activation signals have yet been identified. Abis are widespread in Lactococcus lactis, but regulation of their expression remains an open question. We previously showed that development of AbiD1 abortive infection against phage bIL66 depends on orf1, which is expressed in mid-infection. However, molecular basis for this activation remains unclear.

Results

In non-infected AbiD1+ cells, specific abiD1 mRNA is unstable and present in low amounts.

SUBMITTER: Bidnenko E 

PROVIDER: S-EPMC2661086 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature