Molecular models of human P-glycoprotein in two different catalytic states.

ABSTRACT:

Background

P-glycoprotein belongs to the family of ATP-binding cassette proteins which hydrolyze ATP to catalyse the translocation of their substrates through membranes. This protein extrudes a large range of components out of cells, especially therapeutic agents causing a phenomenon known as multidrug resistance. Because of its clinical interest, its activity and transport function have been largely characterized by various biochemical studies. In the absence of a high-resolution structure of P-glycoprotein, homology modeling is a useful tool to help interpretation of experimental data and potentially guide experimental studies.

Results

We present here three-dimensional models of two different catalytic states of P-glycoprotein that were developed based on the crystal struc

SUBMITTER: Becker JP 

PROVIDER: S-EPMC2661087 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature