Salty dog, an SLC5 symporter, modulates Drosophila response to salt stress.

ABSTRACT: To regulate their internal environments, organisms must adapt to varying ion levels in their diet. Adult Drosophila were exposed to dietary salt stress, and their physiological, survival, and gene expression responses monitored. Insects continued to feed on NaCl-elevated diet, although levels >4% wt/vol ultimately proved fatal. Affymetrix microarray analysis of flies fed on diet containing elevated NaCl showed a phased response: the earliest response was widespread upregulation of immune genes, followed by upregulation of carbohydrate metabolism as the immune response was downregulated, then finally a switch to amino acid catabolism and inhibition of genes associated with the reproductive axis. Significantly, the online transcriptomic resource FlyAtlas reports that most of the modulated ge

SUBMITTER: Stergiopoulos K 

PROVIDER: S-EPMC2661102 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature