Visualizing and quantifying adhesive signals.

ABSTRACT: Understanding the structural adaptation and signaling of adhesion sites in response to mechanical stimuli requires in situ characterization of the dynamic activation of a large number of adhesion components. Here, we review high-resolution live cell imaging approaches to measure forces, assembly, and interaction of adhesion components, and the activation of adhesion-mediated signals. We conclude by outlining computational multiplexing as a framework for the integration of these data into comprehensive models of adhesion signaling pathways.

SUBMITTER: Sabouri-Ghomi M 

PROVIDER: S-EPMC2661108 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature