Breast-feeding modifies the association of PPARgamma2 polymorphism Pro12Ala with growth in early life: the Generation R Study.

ABSTRACT:

Objective

We examined whether the PPARgamma2 Ala12 allele influences growth in early life and whether this association is modified by breast-feeding.

Research design and methods

This study was embedded in the Generation R Study, a prospective cohort study from early fetal life onward. PPARgamma2 was genotyped in DNA obtained from cord blood samples in 3,432 children. Information about breast-feeding was available from questionnaires. Weight, head circumference, and femur length were repeatedly measured in second and third trimesters of pregnancy, at birth, and at the ages of 1.5, 6, 11, 14, and 18 months.

Results

Genotype frequency distribution was 77.6% (Pro12Pro), 20.7% (Pro12Ala), and 1.7% (Ala12Ala). Growth rates in weight from second trimester of pregnancy to 18

SUBMITTER: Mook-Kanamori DO 

PROVIDER: S-EPMC2661583 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature