Common variants of hepatocyte nuclear factor 1beta are associated with type 2 diabetes in a Chinese population.

ABSTRACT:

Objective

Hepatocyte nuclear factor 1beta (HNF1beta) is a transcription factor that is critical for pancreatic cell formation and glucose homeostasis. Previous studies have reported that common variants of HNF1beta were associated with type 2 diabetes in Caucasians and West Africans. However, analysis in the subjects from the Botnia study and Malmö Preventive Project produced conflicting results, and the role for HNF1beta in type 2 diabetes susceptibility remains unclear. We therefore investigated common variants across the HNF1beta gene in a Chinese population.

Research design and methods

Fifteen tagging single nucleotide polymorphisms (SNPs) were analyzed for association with type 2 diabetes in subjects with type 2 diabetes (n = 1,859) and normal glucose regulation (n = 1,

SUBMITTER: Wang C 

PROVIDER: S-EPMC2661584 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature