Sex and depot differences in adipocyte insulin sensitivity and glucose metabolism.

ABSTRACT:

Objective

To investigate how insulin sensitivity and glucose metabolism differ in adipocytes between different fat depots of male and female mice and how sex steroids contribute to these differences.

Research design and methods

Adipocytes from intra-abdominal/perigonadal (PG) and subcutaneous (SC) adipose tissue from normal, castrated, or steroid-implanted animals were isolated and analyzed for differences in insulin sensitivity and glucose metabolism.

Results

Adipocytes from both PG and SC depots of females have increased lipogenic rates compared with those from males. In females, intra-abdominal PG adipocytes are more insulin-sensitive than SC adipocytes and more insulin-sensitive than male adipocytes from either depot. When stimulated by low physiological concentra

SUBMITTER: Macotela Y 

PROVIDER: S-EPMC2661589 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature