Reconstruction and logical modeling of glucose repression signaling pathways in Saccharomyces cerevisiae.

ABSTRACT:

Background

In the yeast Saccharomyces cerevisiae, the presence of high levels of glucose leads to an array of down-regulatory effects known as glucose repression. This process is complex due to the presence of feedback loops and crosstalk between different pathways, complicating the use of intuitive approaches to analyze the system.

Results

We established a logical model of yeast glucose repression, formalized as a hypergraph. The model was constructed based on verified regulatory interactions and it includes 50 gene transcripts, 22 proteins, 5 metabolites and 118 hyperedges. We computed the logical steady states of all nodes in the network in order to simulate wildtype and deletion mutant responses to different sugar availabilities. Evaluation of the model predictive power

SUBMITTER: Christensen TS 

PROVIDER: S-EPMC2661888 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature