A sequential metal-catalyzed C-N bond formation in the synthesis of 2-amido-indoles.

ABSTRACT: A sequential metal-catalyzed C-N bond formation employing ortho-haloaryl acetylenic bromides is described. The initial amidation is highly selective for C (sp)-N bond formation, leading to o-haloaryl-substituted ynamides that can be useful building blocks, while the overall sequence provides a facile construction of 2-amido-indoles.

SUBMITTER: Yao PY 

PROVIDER: S-EPMC2662137 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature