A fluorous-tagged "safety catch" linker for preparing heterocycles by ring-closing metathesis.

ABSTRACT: A fluorous-tagged "safety catch" linker is described for the synthesis of heterocycles with use of ring-closing metathesis. The linker facilitates the purification of metathesis substrates, the removal of the catalyst, the functionalization of the products, and the release of only metathesis products. The synthesis of a range of heterocycles is described.

SUBMITTER: O'Leary-Steele C 

PROVIDER: S-EPMC2662370 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature