Synthesis of (+)-coronafacic acid.

ABSTRACT: An enantioselective synthesis of (+)-coronafacic acid has been achieved. Rhodium-catalyzed cyclization of an alpha-diazoester provided the intermediate cyclopentanone in high enantiomeric purity. Subsequent Fe-mediated cyclocarbonylation of a derived alkenyl cyclopropane gave a bicyclic enone that then was hydrogenated and carried on to the natural product.

SUBMITTER: Taber DF 

PROVIDER: S-EPMC2662389 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature