Global comparative transcriptome analysis of cartilage formation in vivo.

ABSTRACT:

Background

During vertebrate embryogenesis the initial stages of bone formation by endochondral ossification involve the aggregation and proliferation of mesenchymal cells into condensations. Continued growth of the condensations and differentiation of the mesenchymal cells into chondrocytes results in the formation of cartilage templates, or anlagen, which prefigure the shape of the future bones. The chondrocytes in the anlagen further differentiate by undergoing a complex sequence of maturation and hypertrophy, and are eventually replaced by mineralized bone. Regulation of the onset of chondrogenesis is incompletely understood, and would be informed by comprehensive analyses of in vivo gene expression.

Results

Tibial and fibular pre-condensed mesenchyme was microdissected

SUBMITTER: Cameron TL 

PROVIDER: S-EPMC2662817 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature