Monoallelic maternal expression of STAT5A affects embryonic survival in cattle.

ABSTRACT:

Background

Reproductive disorders and infertility are surprisingly common in the human population as well as in other species. The decrease in fertility is a major cause of cow culling and economic loss in the dairy herd. The conception rate has been declining for the past 30-50 years. Conception rate is the product of fertilization and embryonic survival rates. In a previous study, we have identified associations of several single nucleotide polymorphisms (SNPs) in the signal transducer and activator 5A (STAT5A) with fertilization and survival rates in an in vitro experimental system. The objectives of this study are to fine map the STAT5A region in a search for causative mutations and to investigate the parent of origin expression of this gene.

Results

We have performed a

SUBMITTER: Khatib H 

PROVIDER: S-EPMC2662876 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature