Genetic association analysis of functional impairment in chronic obstructive pulmonary disease.

ABSTRACT:

Rationale

Patients with severe chronic obstructive pulmonary disease (COPD) may have varying levels of disability despite similar levels of lung function. This variation may reflect different COPD subtypes, which may have different genetic predispositions.

Objectives

To identify genetic associations for COPD-related phenotypes, including measures of exercise capacity, pulmonary function, and respiratory symptoms.

Methods

In 304 subjects from the National Emphysema Treatment Trial, we genotyped 80 markers in 22 positional and/or biologically plausible candidate genes. Regression models were used to test for association, using a test-replication approach to guard against false-positive results. For significant associations, effect estimates were recalculated using the e

SUBMITTER: Hersh CP 

PROVIDER: S-EPMC2662917 | biostudies-literature | 2006 May

REPOSITORIES: biostudies-literature