Influence of leukotriene pathway polymorphisms on response to montelukast in asthma.

ABSTRACT:

Rationale

Interpatient variability in montelukast response may be related to variation in leukotriene pathway candidate genes.

Objective

To determine associations between polymorphisms in leukotriene pathway candidate genes with outcomes in patients with asthma receiving montelukast for 6 mo who participated in a clinical trial.

Methods

Polymorphisms were typed using Sequenom matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass array spectrometry and published methods; haplotypes were imputed using single nucleotide polymorphism-expectation maximization (SNP-EM). Analysis of variance and logistic regression models were used to test for changes in outcomes by genotype. In addition, chi(2) and likelihood ratio tests were used to test for differenc

SUBMITTER: Lima JJ 

PROVIDER: S-EPMC2662939 | biostudies-literature | 2006 Feb

REPOSITORIES: biostudies-literature