Increased glucocorticoid receptor beta alters steroid response in glucocorticoid-insensitive asthma.

ABSTRACT:

Rationale

Glucocorticoids (GCs) are highly effective in the treatment of asthma. However, some individuals have GC-insensitive asthma.

Objectives

To evaluate the functional response to steroids of bronchoalveolar lavage (BAL) cells from sites of airway inflammation from patients with GC-insensitive versus GC-sensitive asthma. As well, to attempt to define the functional role of glucocorticoid receptor (GCR)beta (a splicing variant, and dominant negative inhibitor of, the classic GCRalpha) in controlling GCRalpha nuclear translocation and transactivation at a molecular level.

Methods and measurements

Fiberoptic bronchoscopy with collection of BAL fluid was performed on seven patients with GC-sensitive asthma and eight patients with GC-insensitive asthma. GCRalpha cellu

SUBMITTER: Goleva E 

PROVIDER: S-EPMC2662945 | biostudies-literature | 2006 Mar

REPOSITORIES: biostudies-literature