Transcriptional signature following inhibition of early-stage cell wall biosynthesis in Staphylococcus aureus.

ABSTRACT: To facilitate mode of action studies on antibacterial inhibitors of early-stage cell wall biosynthesis (CWB), we determined the transcriptional response of Staphylococcus aureus to depletion/inhibition of enzymes in this pathway by DNA microarray analysis. We identified a transcriptional signature distinct from that previously observed following exposure to inhibitors of late-stage CWB.

SUBMITTER: O'Neill AJ 

PROVIDER: S-EPMC2663120 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature