Protein-protein interaction as a predictor of subcellular location.

ABSTRACT:

Background

Many biological processes are mediated by dynamic interactions between and among proteins. In order to interact, two proteins must co-occur spatially and temporally. As protein-protein interactions (PPIs) and subcellular location (SCL) are discovered via separate empirical approaches, PPI and SCL annotations are independent and might complement each other in helping us to understand the role of individual proteins in cellular networks. We expect reliable PPI annotations to show that proteins interacting in vivo are co-located in the same cellular compartment. Our goal here is to evaluate the potential of using PPI annotation in determining SCL of proteins in human, mouse, fly and yeast, and to identify and quantify the factors that contribute to this complementarity.

SUBMITTER: Shin CJ 

PROVIDER: S-EPMC2663780 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature