A multi-valent vaccine approach that elicits broad immunity within an influenza subtype.

ABSTRACT: Vaccines directed toward individual strains of highly variable viruses like influenza lose efficacy when the circulating viruses no longer resemble the vaccine isolate. Historically, inclusion of more than one isolate per subtype of influenza has been limited by the need to include large doses of antigen with typical protein-based vaccine approaches and by concerns that an immunodominant response to one antigen will limit the response to closely related antigens. Here we provide proof of principle demonstrating that a multi-valent vaccine directed against multiple influenza A virus hemagglutinins (HAs) can elicit broad, neutralizing immunity against multiple strains within a single influenza subtype (H3). We employed a DNA vaccine to direct immunity toward the HA component alone, and a liv

SUBMITTER: Huber VC 

PROVIDER: S-EPMC2663794 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature