Ontology highlight
ABSTRACT:
SUBMITTER: O'Hara AJ
PROVIDER: S-EPMC2663814 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
PLoS pathogens 20090417 4
MicroRNAs (miRNA) have emerged as key regulators of cell lineage differentiation and cancer. We used precursor miRNA profiling by a novel real-time QPCR method (i) to define progressive stages of endothelial cell transformation cumulating in Kaposi sarcoma (KS) and (ii) to identify specific miRNAs that serve as biomarkers for tumor progression. We were able to compare primary patient biopsies to well-established culture and mouse tumor models. Loss of mir-221 and gain of mir-15 expression demark ...[more]