Highly efficient molybdenum-based catalysts for enantioselective alkene metathesis.

ABSTRACT: Discovery of efficient catalysts is one of the most compelling objectives of modern chemistry. Chiral catalysts are in particularly high demand, as they facilitate synthesis of enantiomerically enriched small molecules that are critical to developments in medicine, biology and materials science. Especially noteworthy are catalysts that promote-with otherwise inaccessible efficiency and selectivity levels-reactions demonstrated to be of great utility in chemical synthesis. Here we report a class of chiral catalysts that initiate alkene metathesis with very high efficiency and enantioselectivity. Such attributes arise from structural fluxionality of the chiral catalysts and the central role that enhanced electronic factors have in the catalytic cycle. The new catalysts have a stereogenic met

SUBMITTER: Malcolmson SJ 

PROVIDER: S-EPMC2663850 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature