Characterizing the developmental pathways TTF-1, NKX2-8, and PAX9 in lung cancer.

ABSTRACT: We investigated the clinical implications of lung developmental transcription factors (TTF-1, NKX2-8, and PAX9) that we recently discovered as cooperating oncogenes activated by way of gene amplification at chromosome 14q13 in lung cancer. Using stable transfectants of human bronchial epithelial cells, RNA expression profiles (signatures) representing activation of the biological pathways defined by each of the 3 genes were determined and used to risk stratify a non-small-cell lung cancer (NSCLC) clinical data set consisting of 91 early stage tumors. Coactivation of the TTF-1 and NKX2-8 pathways identified a cluster of patients with poor survival, representing approximately 20% of patients with early stage NSCLC, whereas activation of individual pathways did not reveal significant prognost

SUBMITTER: Hsu DS 

PROVIDER: S-EPMC2664027 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature