Human papillomavirus genotype distributions: implications for vaccination and cancer screening in the United States.

ABSTRACT:

Background

Limited data are available describing human papillomavirus (HPV) genotype distributions in cervical cancer in the United States. Such studies are needed to predict how HPV vaccination and HPV-based screening will influence cervical cancer prevention.

Methods

We used the New Mexico Surveillance, Epidemiology, and End Results Registry to ascertain cases of in situ (n = 1213) and invasive (n = 808) cervical cancer diagnosed during 1985-1999 and 1980-1999, respectively, in the state of New Mexico. HPV genotyping was performed using two polymerase chain reaction-based methods on paraffin-embedded tissues from in situ and invasive cancers and on cervical Papanicolaou test specimen from control subjects (ie, women aged 18-40 years attending clinics for routine cervical s

SUBMITTER: Wheeler CM 

PROVIDER: S-EPMC2664090 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature