Validation study of villous atrophy and small intestinal inflammation in Swedish biopsy registers.

ABSTRACT:

Background

Small intestinal biopsy with villous atrophy (VA) is the gold standard for the diagnosis of celiac disease (CD). We validated VA (Marsh 3) and small intestinal inflammation without VA (Marsh 1+2) in Swedish regional biopsy registers.

Methods

All pathology departments in Sweden (n = 28) were searched to identify individuals with VA or duodenal/jejunal inflammation. The validation consisted of blinded examination of biopsy samples, manual review of biopsy reports, web surveys, and patient chart reviews of 121 individuals with VA and 39 with inflammation.

Results

We identified 29,148 individuals with VA and 13,446 individuals with inflammation. In a blinded examination, Swedish pathologists correctly classified 90% of biopsies with VA. Manual screening of 1,53

SUBMITTER: Ludvigsson JF 

PROVIDER: S-EPMC2664822 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature