Mining metastasis related genes by primary-secondary tumor comparisons from large-scale databases.

ABSTRACT:

Background

Metastasis is the most dangerous step in cancer progression and causes more than 90% of cancer death. Although many researchers have been working on biological features and characteristics of metastasis, most of its genetic level processes remain uncertain. Some studies succeeded in elucidating metastasis related genes and pathways, followed by predicting prognosis of cancer patients, but there still is a question whether the result genes or pathways contain enough information and noise features have been controlled appropriately.

Methods

We set four tumor type classes composed of various tumor characteristics such as tissue origin, cellular environment, and metastatic ability. We conducted a set of comparisons among the four tumor classes followed by searching fo

SUBMITTER: Kim S 

PROVIDER: S-EPMC2665050 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature