Mitogen-activated protein kinase inhibition induces translocation of Bmf to promote apoptosis in melanoma.

ABSTRACT: Constitutive activation of the mitogen-activated protein kinase (MAPK) pathway is implicated in the development and progression of many human cancers, including melanoma. Mutually exclusive activating mutations in NRAS or BRAF have been identified in approximately 85% of melanomas, and components of this pathway have been developed as molecular targets for therapeutic intervention. We and others have shown that inhibition of this pathway with specific small molecule MAPK/extracellular signal-regulated kinase kinase (MEK) inhibitors induces a wide range of apoptotic responsiveness in human melanoma cells both in vitro and in vivo. To define the molecular mechanism underlying variable apoptotic sensitivity of melanoma cells to MEK inhibition, we examined the expression and subcellular locali

SUBMITTER: VanBrocklin MW 

PROVIDER: S-EPMC2665192 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature