Ontology highlight
ABSTRACT:
SUBMITTER: Shojaei F
PROVIDER: S-EPMC2665197 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Shojaei Farbod F Wu Xiumin X Qu Xueping X Kowanetz Marcin M Yu Lanlan L Tan Martha M Meng Y Gloria YG Ferrara Napoleone N
Proceedings of the National Academy of Sciences of the United States of America 20090403 16
Recent studies suggest that tumor-associated CD11b(+)Gr1(+) myeloid cells contribute to refractoriness to antiangiogenic therapy with an anti-VEGF-A antibody. However, the mechanisms of peripheral mobilization and tumor-homing of CD11b(+)Gr1(+) cells are unclear. Here, we show that, compared with other cytokines [granulocyte-macrophage colony stimulating factor (GM-CSF), stromal derived factor 1alpha, and placenta growth factor], G-CSF and the G-CSF-induced Bv8 protein have preferential expressi ...[more]