Proepithelin regulates prostate cancer cell biology by promoting cell growth, migration, and anchorage-independent growth.

ABSTRACT: The growth factor proepithelin has recently emerged as an important regulator of transformation in several physiological and pathological systems. In this study, we determined the biological roles of proepithelin in prostate cancer cells using purified human recombinant proepithelin as well as proepithelin-depletion strategies. Proepithelin promoted the migration of androgen-dependent and -independent human prostate cancer cells; androgen-independent DU145 cells were the more responsive. In these cells, proepithelin additionally stimulated wound closure, invasion, and promotion of cell growth in vitro. These effects required the activation of both the Akt and mitogen-activated protein kinase pathways. We have analyzed proepithelin expression levels in different available prostate cancer mi

SUBMITTER: Monami G 

PROVIDER: S-EPMC2665763 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature