Intensive insulin therapy and mortality among critically ill patients: a meta-analysis including NICE-SUGAR study data.

ABSTRACT:

Background

Hyperglycemia is associated with increased mortality in critically ill patients. Randomized trials of intensive insulin therapy have reported inconsistent effects on mortality and increased rates of severe hypoglycemia. We conducted a meta-analysis to update the totality of evidence regarding the influence of intensive insulin therapy compared with conventional insulin therapy on mortality and severe hypoglycemia in the intensive care unit (ICU).

Methods

We conducted searches of electronic databases, abstracts from scientific conferences and bibliographies of relevant articles. We included published randomized controlled trials conducted in the ICU that directly compared intensive insulin therapy with conventional glucose management and that documented mortality.

SUBMITTER: Griesdale DE 

PROVIDER: S-EPMC2665940 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature