Ontology highlight
ABSTRACT:
SUBMITTER: Poulet A
PROVIDER: S-EPMC2666026 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
The EMBO journal 20090205 6
The ability of the telomeric DNA-binding protein, TRF2, to stimulate t-loop formation while preventing t-loop deletion is believed to be crucial to maintain telomere integrity in mammals. However, little is known on the molecular mechanisms behind these properties of TRF2. In this report, we show that TRF2 greatly increases the rate of Holliday junction (HJ) formation and blocks the cleavage by various types of HJ resolving activities, including the newly identified human GEN1 protein. By using ...[more]